Preclinical Evaluation of Caprylic Acid-Fractionated IgG Antivenom for the Treatment of Taipan (Oxyuranus scutellatus) Envenoming in Papua New Guinea
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چکیده
منابع مشابه
Preclinical Evaluation of Caprylic Acid-Fractionated IgG Antivenom for the Treatment of Taipan (Oxyuranus scutellatus) Envenoming in Papua New Guinea
BACKGROUND Snake bite is a common medical emergency in Papua New Guinea (PNG). The taipan, Oxyuranus scutellatus, inflicts a large number of bites that, in the absence of antivenom therapy, result in high mortality. Parenteral administration of antivenoms manufactured in Australia is the current treatment of choice for these envenomings. However, the price of these products is high and has incr...
متن کاملPAPUAN TAIPAN (Oxyuranus scutellatus canni) ENVENOMATION IN RURAL PAPUA NEW GUINEA
Nine cases of serious envenomation following bites by Papuan taipans Oxyuranus scutellatus canni are presented. Eight cases were fatal with contributing factors such as delayed presentation with advanced symptoms, incorrect antivenom administration, failure to recognise key indications of envenoming, lack of antivenom, and delayed administration of correct antivenom. The survival of a single pa...
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A new species of taipan (Elapidae: Oxyuranus) from central Australia
Snakes in the Australo-Papuan elapid genus Oxyuranus are considered to be the most venomous species in the world. A recent expedition to the central ranges of Western Australia discovered a third species, which is described here from the only known specimen. Molecular genetic analyses using mitochondrial nucleotide sequences places the new species as the sister lineage of the two described Oxyu...
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Taicatoxin, isolated from the venom of the Australian taipan snake Oxyuranus scutellatus, has been previously regarded as a specific blocker of high threshold Ca channels in heart. Here we show that taicatoxin (in contrast to a range of other Ca channel blockers) interacts with apamin-sensitive, small conductance, Caactivated potassium channels on both chromaffin cells and in the brain. Taicato...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2011
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0001144